Gancidovir Health Articles | January 8 Jamel Dean Black Jersey , 2010 Adults and children over age 3 months: induction treatment is 5 mgkg I.V. q 12 hours for 14 to 21 days. Maintenance treat-ment is 5 mglkg I.V. daily for 7 days weekly, or 6 mglkg daily for 5 days weekly. Or, 1,000 mg P.O. t.i.d. with food.
HOW SUPPLIED
Capsules: 250 mg Injection: 500 mgvial
ACTION
Inhibits binding of deoxyguanosine triphosphate to DNA polymerase, resulting in inhibition of DNA synthesis.
INDICATIONS & DOSAGE
CMV retinitis in immunocompromised individuals, including patients with AIDS and normal renalfunction-
Dosage adjustment: Refer to package insert for very specific dose adjustments. Dosage is adjusted for patients with impaired renal function and is based on creatinine clearance levels.
Dosage adjustment is necessary in patients with creatinine clearance below 70 mlminute.
Prevention of CMV disease in patients with advanced HIV infection and normal renal function -
Adults: 1,000 mg P.O. t.i.d. with food.
Prevention of CMV disease in transplant recipients with normal renal function-
Adults: 5 mgkg I. V. (given at a constant rate over 1 hour) q 12 hours for 7 to 14 days; then 5 mgkg daily for 7 days weekly Sean Murphy-Bunting Black Jersey , or 6 mgkg daily for 5 days weekly. Duration of therapy depends on degree of immunosuppression.
ADVERSE REACTIONS
CNS: altered dreams, confusion, ataxia, headache, seizures, coma, dizziness Devin White Black Jersey , somnolence, tremor, abnormal thinking, agitation, amnesia, anxiety, neuropathy O. J. Howard Black Jersey , paresthesia, asthenia.
EENT: retinal detachment in CMV retinitis patients.
GI: nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence Vita Vea Black Jersey , dyspepsia, dry mouth.
Other: fever Mike Evans Black Jersey , infection, chills, sepsis, and inflammation, pain, and phlebitis at injection site.
INTERACTIONS
Drug-drug. Cytotoxic drugs: increased toxic effects, especially hematologic effects and stomatitis. Monitor closely. Didanosine: increased plasma levels of didanosine when used concomitantly. Monitor closely.
Imipenemlcilastatin: heightened seizure activity with concomitant use. Monitor closely.
Immunosuppressants (such as azathioprine Jameis Winston Black Jersey , corticosteroids, cyclosporine): enhanced immune and bone marrow suppression. Use together cautiously. Probenecid: increased ganciclovir blood levels. Monitor closely.
Zidovudine: increased incidence of agranulocytosis with concurrent use. Monitor closely.
EFFECTS ON DIAGNOSTIC TESTS
None reported.
CONTRAINDICATIONS
Contraindicated in patients with hyper-sensitivity to drug or acyclovir and in those with an absolute neutrophil count below 500 mm 3 or a platelet count below 25,000 mm 3 .
SPECIAL CONSIDERATIONS
Use cautiously and in reduced dosage in patients with renal dysfunction. Renal function tests must be monitored.
Ganciclovir solution is alkaline; use caution.
Alert: The drug is not for S.C. or I.M. administration.
Because of the frequency of agranulocytosis and thrombocytopenia, neutrophil and platelet counts are obtained every 2 days during twicedaily ganciclovir dosing and at least weekly thereafter.
I.V. administration
The infusion is administered over at least 1 hour. Too-rapid infusions will result in increased toxicity. An infusion pump must be used. Drug is not to be administered via I.V. bolus.
Patient teaching
Adequate hydration is important during therapy.
Report adverse reactions promptly.
Notify health care provider if discomfort occurs at I.V. insertion site.
The drug causes birth defects. If female, use effective birth control methods during treatment; if male, use barrier contraception during, and for at least 90 days following Mike Alstott Black Jersey , treatment with ganciclovir.
With the recent rise in energy costs many people have been looking to alternative sources of energy. One of the greatest energy sources (our sun) is readily available for the taking. We just need to be able to harness it's power. For those interested, below is a brief history of how solar power came to be.
The history of photovoltaic energy (aka. solar cells) started way back in 1876. William Grylls Adams along with a student of his, Richard Day, discovered that when selenium was exposed to light, it produced electricity. An electricity expert, Werner von Siemens, stated that the discovery was "scientifically of the most far-reaching importance". The selenium cells were not efficient Matt Gay Camo Jersey , but it was proved that light, without heat or moving parts, could be converted into electricity.
In 1953, Calvin Fuller, Gerald Pearson, and Daryl Chapin, discovered the silicon solar cell. This cell actually produced enough electricity and was efficient enough to run small electrical devices. The New York Times stated that this discovery was "the beginning of a new era Anthony Nelson Camo Jersey , leading eventually to the realization of harnessing the almost limitless energy of the sun for the uses of civilization."
The year is 1956, and the first solar cells are available commercially. The cost however is far from the reach of everyday people. At $300 for a 1 watt solar cell, the expense was far beyond anyone's means. 1956 started showing us the first solar cells used in toys and radios. These novelty items were the first item to have solar cells available to consumers.
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